![]() ![]() ![]() The Pediatric Acute Lung Injury Consensus Conference (PALICC) guidelines suggest targeting “safe” SpO 2 targets at the lowest possible FiO 2. Both hypoxemia and hyperoxemia should be adequately responded to, either by increasing or lowering the fraction of inspired oxygen (FiO 2), as deteriorations in pulse oximetry (SpO 2) readings are associated with worse outcomes, including a higher mortality ( 1), development of retinopathy, chronic lung disease, and brain injury ( 2). the number of manual changes 1 (0–2), ( P < 0.001).Ĭonclusion: In this randomized crossover trial in pediatric critically ill patients under invasive ventilation with ASV, use of a closed–loop control of FiO 2 titration increased the percentage of time spent within in optimal SpO 2 zones, and increased the total number of FiO 2 changes per patient.Ĭlinical trial registration:, identifier: NCT04568642.Ĭritically ill invasively ventilated children frequently need supplementary oxygen, which is provided in humidified warmed air, either via a stand-alone gas blender or via a blender inside the ventilator. The total number of closed-loop FiO 2 changes per patient was 52 (11.8–67), vs. Findings were similar with the use of closed-loop FiO 2 controller compared to manual titration in patients with ARDS. The percentage of time spent in acceptable, suboptimal and unacceptable zones decreased. The percentage of time spent in optimal SpO 2 zones increased with use of the closed–loop FiO 2 controller vs. Results: We included 30 children with a median age of 21 (11–48) months 12 (40%) children had pediatric ARDS. ![]() Secondary endpoints included the percentage of time spent in acceptable, suboptimal and unacceptable SpO 2 zones, and the total number of FiO 2 changes per patient. The primary endpoint was the percentage of time spent in optimal SpO 2 zones. Methods: This was a randomized crossover clinical trial comparing Adaptive Support Ventilation (ASV) 1.1 with use of a closed–loop FiO 2 system vs. Introduction: We aimed to compare automated ventilation with closed–loop control of the fraction of inspired oxygen (FiO 2) to automated ventilation with manual titrations of the FiO 2 with respect to time spent in predefined pulse oximetry (SpO 2) zones in pediatric critically ill patients. 3Department of Intensive Care, Amsterdam UMC, Location “Academic Medical Center”, Amsterdam, Netherlands.2Department of Medical Research, Hamilton Medical AG, Bonaduz, Switzerland.Behcet Uz Children's Disease and Surgery Training and Research Hospital, Health Sciences University, Izmir, Turkey 1Department of Pediatric Intensive Care Unit, Dr.Ekin Soydan 1, Gokhan Ceylan 1,2 *, Sevgi Topal 1, Pinar Hepduman 1, Gulhan Atakul 1, Mustafa Colak 1, Ozlem Sandal 1, Ferhat Sari 1, Utku Karaarslan 1, Dominik Novotni 2, Marcus J. ![]()
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